Anytime you put your luggage into someone else's care- a checked bag at an airline, a bellman at the hotel, or handing it to a cruise porter - there's a chance it can be lost.
The first thing people will ask is what does it look like. Since many people have similar, you will want to know how to distinguish your bag. A picture can help as can having a distinctive luggage tag, strap or ribbon tied to the handle. You should also add these distinctive features to your carry on baggage to lower the risk of someone taking your bag by mistake.